Click here full Prescribing Information.
For more information, please go to


  • For insured patients only
  • Eligible commercially insured and covered patients may pay as little as $10/fill for each fill of a YONSA® prescription, subject to a maximum program benefit per fill
  • Present card to pharmacy
  • Maximum benefit of up to $12,000 per calendar year on your YONSA® prescription*
Sun Pharma reserves the right to rescind, revoke or amend this offer at any time.
*Subject to applicable program maximum restrictions, terms and conditions and eligibility criteria described below.



Eligible commercially insured patients 18 years or older pay as little as $10/month for a YONSA® prescription. Patients must have a valid prescription and commercial, prescription drug insurance coverage. To enroll in the YONSA® Co-Pay Program (this "Program"), present the Program card along with a valid prescription to the pharmacist at any participating pharmacy.
Terms and Conditions: By enrolling in the Program, you are certifying that you understand these terms and conditions and that you have/will respond truthfully to the questions presented to you for enrollment. Eligibility: The Program is limited to patients residing in the United States, Puerto Rico, Guam, and the Virgin Islands, excluding patients residing in Massachusetts (effective January 1, 2021). If the FDA approves a therapeutically equivalent Rx drug or if an OTC drug containing abiraterone acetate (the active ingredient in YONSA®) becomes available, the Program will exclude patients residing in California. The Program is not open to patients with no insurance coverage, who have coverage that imposes no co-pay or co-insurance charge (i.e. insurance covering the full cost of YONSA®), or who are covered by a government program including: Medicare, Medicaid, TRICARE, the Veterans Affairs, the Department of Defense, or have prescription drug coverage under any other federal or state program. In addition, if a patient obtains coverage from such a government program after enrolling in this program, he/she will not be eligible to continue in the Co-Pay Program. Maximum Benefit: The maximum benefit allowed under the Program is $12,000 in each calendar year and no more than $5,000 for each individual prescription filled. Additional Requirements: This offer is not transferable and cannot be combined with any other offer, free trial, prescription savings card, or discount. Participation in the Program is not conditioned on any past, present, or future purchase. Patients may not apply for reimbursement for all or any part of any benefit they receive from their health insurance or any third party and must report to their insurer or health plan administrator, if required, that they have enrolled in this program and are/will receive a financial benefit. The Program card is accepted only at participating pharmacies. There may be additional terms and conditions that also apply. Legal Notice: This Program is not health insurance. This Program is void where prohibited or restricted by law. Any sale, purchase, trade, counterfeiting, duplication, or reproduction of this card or offer to do so, is prohibited by law. Term: This offer expires on 3/31/2021 but may be canceled or changed, without notice, at any time. Use of Personal Data: Data related to your redemption of the card may be collected, combined with data from other co-pay card redemptions, de-identified, and shared with the Program sponsor (Sun Pharmaceutical Industries, Inc.), for market research, program assessment, and for other lawful purposes.



YONSA® (abiraterone acetate) in combination with methylprednisolone is indicated for the treatment of patients with metastatic castration-resistant prostate cancer (CRPC).

Important Administration Instructions

YONSA® may not be interchangeable with other abiraterone acetate products. To avoid substitution errors and overdose, be aware that YONSA® tablets may have different dosing and food effects than other abiraterone acetate products. Patients receiving YONSA® should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy.

Important Safety Information


YONSA® can cause fetal harm and potential loss of pregnancy.


Hypertension, Hypokalemia, and Fluid Retention Due to Mineralocorticoid Excess: YONSA® may cause hypertension, hypokalemia, and fluid retention as a consequence of increased mineralocorticoid levels resulting from CYP17 inhibition. Monitor patients for hypertension, hypokalemia, and fluid retention at least once a month. Control hypertension and correct hypokalemia before and during treatment with YONSA®.

Closely monitor patients whose underlying medical conditions might be compromised by increases in blood pressure, hypokalemia or fluid retention, such as those with heart failure, recent myocardial infarction, cardiovascular disease, or ventricular arrhythmia. The safety of YONSA® in patients with left ventricular ejection fraction < 50% or New York Heart Association (NYHA) Class III or IV heart failure (in Study 1) or NYHA Class II to IV heart failure (in Study 2) was not established because these patients were excluded from these randomized clinical trials.

Adrenocortical Insufficiency (AI): AI was reported in patients receiving abiraterone acetate in combination with corticosteroid, following an interruption of daily steroids and/or with concurrent infection or stress. Monitor patients for symptoms and signs of AI, particularly if patients are withdrawn from corticosteroids, have corticosteroid dose reductions, or experience unusual stress. Symptoms and signs of AI may be masked by adverse reactions associated with mineralocorticoid excess seen in patients treated with YONSA®. Perform appropriate tests, if indicated, to confirm AI. Increased dosages of corticosteroids may be used before, during, and after stressful situations.

Hepatotoxicity: In postmarketing experience, there have been abiraterone acetate-associated severe hepatic toxicity, including fulminant hepatitis, acute liver failure and deaths. Measure serum transaminases (ALT and AST) and bilirubin levels prior to starting treatment with YONSA®, every two weeks for the first three months of treatment and monthly thereafter. In patients with baseline moderate hepatic impairment receiving a reduced YONSA® dose of 125 mg, measure ALT, AST, and bilirubin prior to the start of treatment, every week for the first month, every two weeks for the following two months of treatment and monthly thereafter. Promptly measure serum total bilirubin, AST, and ALT if clinical symptoms or signs suggestive of hepatotoxicity develop. Elevations of AST, ALT, or bilirubin from the patient's baseline should prompt more frequent monitoring. If at any time AST or ALT rise above five times the ULN, or the bilirubin rises above three times the ULN, interrupt YONSA® treatment and closely monitor liver function.

Re-treatment with YONSA® at a reduced dose level may take place only after return of liver function tests to the patient's baseline or to AST and ALT less than or equal to 2.5X ULN and total bilirubin less than or equal to 1.5X ULN.

Permanently discontinue treatment with abiraterone acetate for patients who develop a concurrent elevation of ALT greater than 3 x ULN and total bilirubin greater than 2 x ULN in the absence of biliary obstruction or other causes responsible for the concurrent elevation.

The safety of YONSA® re-treatment of patients who develop AST or ALT greater than or equal to 20X ULN and/or bilirubin greater than or equal to 10X ULN is unknown.


The most common adverse reactions (≥10%) are fatigue, joint swelling or discomfort, edema, hot flush, diarrhea, vomiting, cough, hypertension, dyspnea, urinary tract infection and contusion.

The most common laboratory abnormalities (>20%) are anemia, elevated alkaline phosphatase, hypertriglyceridemia, lymphopenia, hypercholesterolemia, hyperglycemia, elevated AST, hypophosphatemia, elevated ALT and hypokalemia.


Based on in vitro data, YONSA® is a substrate of CYP3A4. In a drug interaction trial, co-administration of rifampin, a strong CYP3A4 inducer, decreased exposure of abiraterone by 55%. Avoid concomitant strong CYP3A4 inducers during YONSA® treatment. If a strong CYP3A4 inducer must be co-administered, increase the YONSA® dosing frequency only during the co-administration period.

Abiraterone is an inhibitor of the hepatic drug-metabolizing enzymes CYP2D6 and CYP2C8. Avoid coadministration of abiraterone acetate with substrates of CYP2D6 with a narrow therapeutic index (e.g., thioridazine). If alternative treatments cannot be used, exercise caution and consider a dose reduction of the concomitant CYP2D6 substrate drug.

In a CYP2C8 drug-drug interaction trial in healthy subjects, the AUC of pioglitazone (CYP2C8 substrate) was increased by 46% when pioglitazone was given together with an abiraterone acetate single dose equivalent to YONSA® 500 mg. Therefore, patients should be monitored closely for signs of toxicity related to a CYP2C8 substrate with a narrow therapeutic index if used concomitantly with abiraterone acetate.


  • Females and Males of Reproductive Potential: Advise male patients with female partners of reproductive potential to use effective contraception.
  • Do not use YONSA® in patients with baseline severe hepatic impairment (Child-Pugh Class C).
Please see Full Prescribing Information for YONSA® at